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31/07/2020 Original Investigation
Assessment of SARS-CoV-2 Screening Strategies to Permit the Safe Reope...

Assessment of SARS-CoV-2 Screening Strategies to Permit the Safe Reopening of College Campuses in the United States

JAMA

Authors
A. David Paltiel, Amy Zheng, Rochelle P. Walensky



ABSTRACT
Importance The coronavirus disease 2019 (COVID-19) pandemic poses an existential threat to many US residential colleges; either they open their doors to students in September or they risk serious financial consequences.
Objective To define severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) screening performance standards that would permit the safe return of students to US residential college campuses for the fall 2020 semester.
Design, Setting, and Participants This analytic modeling study included a hypothetical cohort of 4990 students without SARS-CoV-2 infection and 10 with undetected, asymptomatic SARS-CoV-2 infection at the start of the semester. The decision and cost-effectiveness analyses were linked to a compartmental epidemic model to evaluate symptom-based screening and tests of varying frequency (ie, every 1, 2, 3, and 7 days), sensitivity (ie, 70%-99%), specificity (ie, 98%-99.7%), and cost (ie, $10/test-$50/test). Reproductive numbers (Rt) were 1.5, 2.5, and 3.5, defining 3 epidemic scenarios, with additional infections imported via exogenous shocks. The model assumed a symptomatic case fatality risk of 0.05% and a 30% probability that infection would eventually lead to observable COVID-19–defining symptoms in the cohort. Model projections were for an 80-day, abbreviated fall 2020 semester. This study adhered to US government guidance for parameterization data.
Main Outcomes and Measures Cumulative tests, infections, and costs; daily isolation dormitory census; incremental cost-effectiveness; and budget impact.
Results At the start of the semester, the hypothetical cohort of 5000 students included 4990 (99.8%) with no SARS-CoV-2 infection and 10 (0.2%) with SARS-CoV-2 infection. Assuming an Rt of 2.5 and daily screening with 70% sensitivity, a test with 98% specificity yielded 162 cumulative student infections and a mean isolation dormitory daily census of 116, with 21 students (18%) with true-positive results. Screening every 2 days resulted in 243 cumulative infections and a mean daily isolation census of 76, with 28 students (37%) with true-positive results. Screening every 7 days resulted in 1840 cumulative infections and a mean daily isolation census of 121 students, with 108 students (90%) with true-positive results. Across all scenarios, test frequency was more strongly associated with cumulative infection than test sensitivity. This model did not identify symptom-based screening alone as sufficient to contain an outbreak under any of the scenarios we considered. Cost-effectiveness analysis selected screening with a test with 70% sensitivity every 2, 1, or 7 days as the preferred strategy for an Rt of 2.5, 3.5, or 1.5, respectively, implying screening costs of $470, $910, or $120, respectively, per student per semester.
Conclusions and Relevance In this analytic modeling study, screening every 2 days using a rapid, inexpensive, and even poorly sensitive (>70%) test, coupled with strict behavioral interventions to keep Rt less than 2.5, is estimated to maintain a controllable number of COVID-19 infections and permit the safe return of students to campus.


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28/07/2020 Link
THE COVID-19 HOST GENETICS INITIATIVE

COVID-19 HG

Authors
COVID-19 hg


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24/07/2020 Original Investigation
Knowledge, Concerns, and Behaviors of Individuals During the First Wee...

Knowledge, Concerns, and Behaviors of Individuals During the First Week of the Coronavirus Disease 2019 Pandemic in Italy

JAMA

Authors
Francesco Pagnini, Andrea Bonanomi, Semira Tagliabue, Michela Balconi, Mauro Bertolotti, Emanuela Confalonieri, Cinzia Di Dio, Gabriella Gilli, Guendalina Graffigna, Camillo Regalia, Emanuela Saita, Daniela Villani



ABSTRACT
Importance At the beginning of a public health crisis, such as the coronavirus disease 2019 (COVID-19) pandemic, it is important to collect information about people’s knowledge, worries, and behaviors to examine their influence on quality of life and to understand individual characteristics associated with these reactions. Such information could help to guide health authorities in providing informed interventions and clear communications.
Objectives To document the initial knowledge about COVID-19 and recommended health behaviors; to assess worries (ie, one’s perception of the influence of the worries of others on oneself), social appraisal, and preventive behaviors, comparing respondents from areas under different movement restrictions during the first week after the outbreak; and to understand how worries, perceived risk, and preventive behaviors were associated with quality of life and individual characteristics among Italian adults.
Design, Setting, and Participants This convenience sample, nonprobablistic survey study recruited adult participants with a snowballing sampling method in any Italian region during the first week of the COVID-19 outbreak in Italy from February 26, 2020, to March 4, 2020. Data were analyzed from March 5 to 12, 2020.
Exposures Information was collected from citizens living in the quarantine zone (ie, red zone), area with restricted movements (ie, yellow zone), and COVID-19–free regions (ie, green zone).
Main Outcomes and Measures Levels of knowledge on the virus, contagion-related worries, social appraisal, and preventive behaviors were assessed with ratings of quality of life (measured using the Short Form Health Survey). Additionally, some individual characteristics that may be associated with worries and behaviors were assessed, including demographic characteristics, personality traits (measured using Big Five Inventory-10), perceived health control (measured using the internal control measure in the Health Locus of Control scale), optimism (measured using the Revised Life Orientation Test), and the need for cognitive closure (measured using the Need for Closure Scale).
Results A total of 3109 individuals accessed the online questionnaire, and 2886 individuals responded to the questionnaire at least partially (mean [SD] age, 30.7 [13.2] years; 2203 [76.3%] women). Most participants were well informed about the virus characteristics and suggested behaviors, with a mean (SD) score of 77.4% (17.3%) correct answers. Quality of life was similar across the 3 zones (effect size = 0.02), but mental health was negatively associated with contagion-related worries (β = –0.066), social appraisal (β = –0.221), and preventive behaviors (β = –0.066) in the yellow zone (R2 = 0.108). Social appraisal was also associated with reduced psychological well-being in the green zone (β = –0.205; R2 = 0.121). In the yellow zone, higher worries were negatively correlated with emotional stability (β = –0.165; R2 = 0.047). Emotional stability was also negatively associated with perceived susceptibility in the yellow (β = –0.108; R2 = 0.040) and green (β = –0.170; R2 = 0.087) zones. Preventative behaviors and social appraisal were also associated with the need for cognitive closure in both yellow (preventive behavior: β = 0.110; R2 = 0.023; social appraisal β = 0.115; R2 = 0.104) and green (preventive behavior: β = 0.174; R2 = 0.022; social appraisal: 0.261; R2 = 0.137) zones.
Conclusions and Relevance These findings suggest that during the first week of the COVID-19 outbreak in Italy, people were well informed and had a relatively stable level of worries. Quality of life did not vary across the areas, although mental well-being was challenged by the social appraisal and worries related to the contagion. Increased scores for worries and concerns were associated with more cognitive rigidity and emotional instability.

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24/07/2020 Editorial
Covid-19: arrivare preparati all’autunno

E&P (EPIDEMIOLOGIA E PREVENZIONE)

Authors
Paolo Vineis, Lucia Bisceglia, Francesco Forastiere, Stefania Salmaso, Salvatore Scondotto



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22/07/2020 Press Release
New COVID-19 Law Lab to provide vital legal information and support fo...

New COVID-19 Law Lab to provide vital legal information and support for the global COVID-19 response

WHO (WORLD HEALTH ORGANIZATION)

Authors
WHO (WORLD HEALTH ORGANIZATION)



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22/07/2020 HEALTHCARE WORKERS
Duration of Isolation and Precautions for Adults with COVID-19

CDC (CENTER FOR DISEASE CONTROL AND PREVENTION)

Authors
National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases home



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22/07/2020 Report
Effectiveness of Cloth Masks for Protection Against Severe Acute Respi...

Effectiveness of Cloth Masks for Protection Against Severe Acute Respiratory Syndrome Coronavirus 2

CDC (CENTER FOR DISEASE CONTROL AND PREVENTION)

Authors
Abrar A. Chughtai, Holly Seale, C. Raina Macintyre



ABSTRACT
Cloth masks have been used in healthcare and community settings to protect the wearer from respiratory infections. The use of cloth masks during the coronavirus disease (COVID-19) pandemic is under debate. The filtration effectiveness of cloth masks is generally lower than that of medical masks and respirators; however, cloth masks may provide some protection if well designed and used correctly. Multilayer cloth masks, designed to fit around the face and made of water-resistant fabric with a high number of threads and finer weave, may provide reasonable protection. Until a cloth mask design is proven to be equally effective as a medical or N95 mask, wearing cloth masks should not be mandated for healthcare workers. In community settings, however, cloth masks may be used to prevent community spread of infections by sick or asymptomatically infected persons, and the public should be educated about their correct use.

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13/07/2020 Research
Lockdown timing and efficacy in controlling COVID-19 using mobile phon...

Lockdown timing and efficacy in controlling COVID-19 using mobile phone tracking

THE LANCET

Authors
Marco Vinceti Tommaso Filippini Kenneth J. Rothman Fabrizio Ferrari Alessia Goffi Giuseppe Maffeis Nicola Orsini



ABSTRACT
Background Italy's severe COVID-19 outbreak was addressed by a lockdown that gradually increased in space, time and intensity. The effectiveness of the lockdown has not been precisely assessed with respect to the intensity of mobility restriction and the time until the outbreak receded. Methods We used processed mobile phone tracking data to measure mobility restriction, and related those data to the number of new SARS-CoV-2 positive cases detected on a daily base in the three most affected Italian regions, Lombardy, Veneto and Emilia-Romagna, from February 1 through April 6, 2020, when two subsequent lockdowns with increasing intensity were implemented by the Italian government. Findings During the study period, mobility restriction was inversely related to the daily number of newly diagnosed SARS-CoV-2 positive cases only after the second, more effective lockdown, with a peak in the curve of diagnosed cases of infection occurring 14 to 18 days from lockdown in the three regions and 9 to 25 days in the included provinces. An effective reduction in transmission must have occurred nearly immediately after the tighter lockdown, given the lag time of around 10 days from asymptomatic infection to diagnosis. The period from lockdown to peak was shorter in the areas with the highest prevalence of the infection. This effect was seen within slightly more than one week in the most severely affected areas. Interpretation It appears that the less rigid lockdown led to an insufficient decrease in mobility to reverse an outbreak such as COVID-19. With a tighter lockdown, mobility decreased enough to bring down transmission promptly below the level needed to sustain the epidemic. Funding No funding sources have been used for this work.

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08/07/2020 Paper
Triage of patients with venous and lymphatic diseases during the COVID...

Triage of patients with venous and lymphatic diseases during the COVID-19 pandemic – The Venous and Lymphatic Triage and Acuity Scale (VELTAS):

SAGE JOURNALS

Authors
Kurosh Parsi, Andre M van Rij, Mark H Meissner, Alun H Davies, Marianne De Maeseneer, Peter Gloviczki, Stephen Benson, Oscar Bottini, Victor Manuel Canata, Paul Dinnen, Antonios Gasparis, Sergio Gianesini, David Huber, David Jenkins, Brajesh K Lal, Lowell Kabnick, Adrian Lim, William Marston, Alberto Martinez Granados, Nick Morrison, Andrew Nicolaides, Peter Paraskevas, Malay Patel, Stefania Roberts, Christopher Rogan, Marlin W Schul, Pedro Komlos, Andrew Stirling, Simon Thibault, Roy Varghese, Harold J Welch, Cees HA Wittens



ABSTRACT
The coronavirus disease 2019 (COVID-19) global pandemic has resulted in diversion of healthcare resources to the management of patients infected with SARS-CoV-2 virus. Elective interventions and surgical procedures in most countries have been postponed and operating room resources have been diverted to manage the pandemic. The Venous and Lymphatic Triage and Acuity Scale was developed to provide an international standard to rationalise and harmonise the management of patients with venous and lymphatic disorders or vascular anomalies. Triage urgency was determined based on clinical assessment of urgency with which a patient would require medical treatment or surgical intervention. Clinical conditions were classified into six categories of: (1) venous thromboembolism (VTE), (2) chronic venous disease, (3) vascular anomalies, (4) venous trauma, (5) venous compression and (6) lymphatic disease. Triage urgency was categorised into four groups and individual conditions were allocated to each class of triage. These included (1) medical emergencies (requiring immediate attendance), example massive pulmonary embolism; (2) urgent (to be seen as soon as possible), example deep vein thrombosis; (3) semi-urgent (to be attended to within 30–90 days), example highly symptomatic chronic venous disease, and (4) discretionary/non-urgent- (to be seen within 6–12 months), example chronic lymphoedema. Venous and Lymphatic Triage and Acuity Scale aims to standardise the triage of patients with venous and lymphatic disease or vascular anomalies by providing an international consensus-based classification of clinical categories and triage urgency. The scale may be used during pandemics such as the current COVID-19 crisis but may also be used as a general framework to classify urgency of the listed conditions.

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02/07/2020 Technical Report
Use of gloves in healthcare and non- healthcare settings in the contex...

Use of gloves in healthcare and non- healthcare settings in the context of the COVID-19 pandemic"

ECDC

Authors
ECDC

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01/07/2020 Articles
Agents and robots for collaborating and supporting physicians in healt...

Agents and robots for collaborating and supporting physicians in healthcare scenarios

ELSEVIER

Authors
Francesco Lanza, Valeria Seidita, Antonio Chella

Monitoring patients through robotics telehealth systems is an interesting scenario where patients’ conditions, and their environment, are dynamic and unknown variables. We propose to improve telehealth systems’ features to include the ability to serve patients with their needs, operating as human caregivers. The objective is to support the independent living of patients at home without losing the opportunity to monitor their health status. Application scenarios are several, and they spread from simple clinical assisting scenarios to an emergency one. For instance, in the case of a nursing home, the system would support in continuously monitoring the elderly patients. In contrast, in the case of an epidemic diffusion, such as COVID-19 pandemic, the system may help in all the early triage phases, significantly reducing the risk of contagion. However, the system has to let medical assistants perform actions remotely such as changing therapies or interacting with patients that need support. The paper proposes and describes a multi-agent architecture for intelligent medical care. We propose to use the beliefs-desires-intentions agent architecture, part of it is devised to be deployed in a robot. The result is an intelligent system that may allow robots the ability to select the most useful plan for unhandled situations and to communicate the choice to the physician for his validation and permission.

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30/06/2020 Insights
Reopening US Schools in the Era of COVID-19: Practical Guidance From O...

Reopening US Schools in the Era of COVID-19: Practical Guidance From Other Nations

JAMA

Authors
Lala Tanmoy Das, Erika L. Abramson, Rainu Kaushal

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30/06/2020 Guidelines
COVID-19 Aviation Health Safety Protocol Operational guidelines for th...

COVID-19 Aviation Health Safety Protocol Operational guidelines for the management of air passengers and aviation personnel to the COVID-19 pandemic"

EUROPEAN UNION AVIATION SAFETY AGENCY (EASA) - EUROPEAN CENTRE FOR DISEASE PREVENTION AND CONTROL (ECDC)

Authors
European Union Aviation Safety Agency (EASA) - European Centre for Disease Prevention and Control (ECDC)

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29/06/2020 Health Policy
Digital tools against COVID-19: taxonomy, ethical challenges, and navi...

Digital tools against COVID-19: taxonomy, ethical challenges, and navigation aid

THE LANCET

Authors
Urs Gasser, Marcello Ienca, James Scheibner, Joanna Sleigh, Effy Vayena


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29/06/2020 Viewpoint
Applications of digital technology in COVID-19 pandemic planning and r...

Applications of digital technology in COVID-19 pandemic planning and response

THE LANCET

Authors
Sera Whitelaw, Mamas A Mamas, Eric Topol, Harriette G C Van Spall


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27/06/2020 Comment
Offline: The second wave

THE LANCET

Authors
Richard Horton


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26/06/2020 PERSPECTIVE
Reducing transmission of SARS-CoV-2

SCIENCE

Authors
Kimberly A. Prather, Chia C. Wang, Robert T. Schooley


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25/06/2020 Q&A DETAIL
Q&A: Dexamethasone and COVID-19

WORLD HEALTH ORGANIZATION

Authors
WHO TEAM


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18/06/2020 Viewpoint
Special considerations in the management of adult patients with acute ...

Special considerations in the management of adult patients with acute leukaemias and myeloid neoplasms in the COVID-19 era: recommendations from a panel of international experts

THE LANCET

Authors
Amer M Zeidan*, Prajwal C Boddu*, Mrinal M Patnaik, Jan Philipp Bewersdorf, Maximilian Stahl, Raajit K Rampal, Rory Shallis, David P Steensma, Michael R Savona, Mikkael A Sekeres, Gail J Roboz, Daniel J DeAngelo, Andre C Schuh, Eric Padron, Joshua F Zeidner, Roland B Walter, Francesco Onida, Amir Fathi, Amy DeZern, Gabriela Hobbs, Eytan M Stein, Paresh Vyas, Andrew H Wei, David T Bowen, Pau Montesinos,Elizabeth A Griffiths, Amit K Verma, Alla Keyzner, Michal Bar-Natan, Shyamala C Navada , Marina Kremyanskaya, Aaron D Goldberg, Aref Al-Kali, Mark L Heaney, Aziz Nazha, Huda Salman, Selina Luger, Keith W Pratz, Heiko Konig, Rami Komrokji, Michael Deininger, Blanca Xicoy Cirici, Vijaya Raj Bhatt, Lewis R Silverman, Harry P Erba, Pierre Fenaux, Uwe Platzbecker, Valeria Santini, Eunice S Wang, Martin S Tallman, Richard M Stone, John Mascarenhas


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18/06/2020 Viewpoint
Special considerations in the management of adult patients with acute ...

Special considerations in the management of adult patients with acute leukaemias and myeloid neoplasms in the COVID-19 era: recommendations from a panel of international experts

THE LANCET

Authors
Amer M Zeidan*, Prajwal C Boddu*, Mrinal M Patnaik, Jan Philipp Bewersdorf, Maximilian Stahl, Raajit K Rampal, Rory Shallis, David P Steensma, Michael R Savona, Mikkael A Sekeres, Gail J Roboz, Daniel J DeAngelo, Andre C Schuh, Eric Padron, Joshua F Zeidner, Roland B Walter, Francesco Onida, Amir Fathi, Amy DeZern, Gabriela Hobbs, Eytan M Stein, Paresh Vyas, Andrew H Wei, David T Bowen, Pau Montesinos,Elizabeth A Griffiths, Amit K Verma, Alla Keyzner, Michal Bar-Natan, Shyamala C Navada , Marina Kremyanskaya, Aaron D Goldberg, Aref Al-Kali, Mark L Heaney, Aziz Nazha, Huda Salman, Selina Luger, Keith W Pratz, Heiko Konig, Rami Komrokji, Michael Deininger, Blanca Xicoy Cirici, Vijaya Raj Bhatt, Lewis R Silverman, Harry P Erba, Pierre Fenaux, Uwe Platzbecker, Valeria Santini, Eunice S Wang, Martin S Tallman, Richard M Stone, John Mascarenhas


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18/06/2020 Press Release
Coronavirus: Using European supercomputing, EU-funded research project...

Coronavirus: Using European supercomputing, EU-funded research project announces promising results for potential treatment

EUROPEAN COMMISSION

Authors
EUROPEAN COMMISSION


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15/06/2020 Articles
Cardiac rehabilitation activities during the COVID-19 pandemic in Ital...

Cardiac rehabilitation activities during the COVID-19 pandemic in Italy. Position Paper of the AICPR (Italian Association of Clinical Cardiology, Prevention and Rehabilitation)

MONALDI ARCHIVES FOR CHEST DISEASE 2020

Authors
Antonio Mazza, Roberto Pedretti, Filippo Sarullo, Francesco Fattirolli, Pompilio Faggiano, Francesco Giallauria, Carlo Vigorito, Elisabetta Angelino, Silvia Brazzo, Matteo Ruzzolini


ABSTRACT
The COVID-19 outbreak is having a significant impact on both cardiac rehabilitation (CR) inpatient and outpatient healthcare organization. The variety of clinical and care scenarios we are observing in Italy depends on the region, the organization of local services and the hospital involved. Some hospital wards have been closed to make room to dedicated beds or to quarantine the exposed health personnel. In other cases, CR units have been converted or transformed into COVID-19 units. The present document aims at defining the state of the art of CR during COVID-19 pandemic, through the description of the clinical and management scenarios frequently observed during this period and the exploration of the future frontiers in the management of cardiac rehabilitation programs after the COVID-19 outbreak.

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14/06/2020 Reviews
A compendium answering 150 questions on COVID-19 and SARS-CoV-2

WILEY ONLINE LIBRARY

Authors
Carmen Riggioni, Pasquale Comberiati, Mattia Giovannini, Ioana Agache, Mübeccel Akdis, Magna Alves‐Correia, Josep M. Antó, Alessandra Arcolaci, Ahmet Kursat Azkur, Dilek Azkur, Burcin Beken, Cristina Boccabella, Jean Bousquet, Heimo Breiteneder, Daniela Carvalho, Leticia De las Vecillas, Zuzana Diamant, Ibon Eguiluz‐Gracia, Thomas Eiwegger, Stefanie Eyerich, Wytske Fokkens, Ya‐dong Gao, Farah Hannachi, Sebastian L. Johnston, Marek Jutel, Aspasia Karavelia, Ludger Klimek, Beatriz Moya, Kari Nadeau, Robyn O'Hehir, Liam O'Mahony, Oliver Pfaar, Marek Sanak, Jürgen Schwarze, Milena Sokolowska, María J. Torres, Willem van de Veen, Menno C. van Zelm, De Yun Wang, Luo Zhang, Rodrigo Jiménez‐Saiz, Cezmi A. Akdis



ABSTRACT
In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date it has resulted in~5.6 million confirmed cases and caused 353,334 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a "cytokine storm" leading to acute respiratory distress syndrome, endothelitis, thrombo-embolic complications and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19 and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development and epidemiology. Over 140 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.

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09/06/2020 Institutional Recommendations
The Covid crisis and a possible turning point for the European Union S...

The Covid crisis and a possible turning point for the European Union Statement by the Lincei Committee on Covid-19

ACCADEMIA NAZIONALE DEI LINCEI

Authors
Lincei Committee on Covid-19



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07/06/2020 INSTITUTIONAL RECOMMENDATION
Covid-19: Fair Access to Vaccines Statement by the Lincei Committee on...

Covid-19: Fair Access to Vaccines Statement by the Lincei Committee on Covid-19

ACCADEMIA NAZIONALE DEI LINCEI

Authors
Commissione Covid-19 ACCADEMIA NAZIONALE DEI LINCEI


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05/06/2020 Guidelines
Advice on the use of masks in the context of COVID-19

WORLD HEALTH ORGANIZATION

Authors
WORLD HEALTH ORGANIZATION


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04/06/2020 Communication
High impact of COVID-19 in long-term care facilities, suggestion for m...

High impact of COVID-19 in long-term care facilities, suggestion for monitoring in the EU/EEA, May 2020

EUROSURVEILLANCE

Authors
Kostas Danis, Laure Fonteneau, Scarlett Georges, Côme Daniau, Sibylle Bernard- Stoecklin, Lisa Domegan, Joan O’Donnell, Siri Helene Hauge, Sara Dequeker, Eline Vandael, Johan Van der Heyden, Françoise Renard, Natalia Bustos Sierra, Enrico Ricchizzi, Birgitta Schweickert, Nicole Schmidt, Muna Abu Sin, Tim Eckmanns, José-Artur Paiva , Elke Schneider



ABSTRACT
Residents in long-term care facilities (LTCF) are a vulnerable population group. Coronavirus disease (COVID-19)-related deaths in LTCF residents represent 30–60% of all COVID-19 deaths in many European countries. This situation demands that countries implement local and national testing, infection prevention and control, and monitoring programmes for COVID-19 in LTCF in order to identify clusters early, decrease the spread within and between facilities and reduce the size and severity of outbreaks.

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03/06/2020 SPEECHES
WHO Director-General's opening remarks at the media briefing on COVID-...

WHO Director-General's opening remarks at the media briefing on COVID-19

WORLD HEALTH ORGANIZATION

Authors
WORLD HEALTH ORGANIZATION

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03/06/2020 STATEMENT
Medicines assessment during public health emergencies needs good scien...

Medicines assessment during public health emergencies needs good science, best practices and proper communication

CIOMS

Authors
Council for International Organizations of Medical Sciences (CIOMS) International Expert Working Group

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29/05/2020 Guidelines
Ricerca e gestione dei contatti di casi COVID-19 (Contact tracing) ed ...

Ricerca e gestione dei contatti di casi COVID-19 (Contact tracing) ed App Immuni.

MINISTERO DELLA SALUTE

Authors
DIREZIONE GENERALE DELLA PREVENZIONE SANITARIA, DIREZIONE GENERALE DELLA PROGRAMMAZIONE SANITARIA, DIREZIONE GENERALE DELLA DIGITALIZZAZIONE, DEL SISTEMA INFORMATIVO SANITARIO E DELLA STATISTICA

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27/05/2020 Guidelines
Clinical management of COVID-19: interim guidance

WORLD HEALTH ORGANIZATION

Authors
WORLD HEALTH ORGANIZATION

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27/05/2020 Viewpoint
Digital Smartphone Tracking for COVID-19 Public Health and Civil Liber...

Digital Smartphone Tracking for COVID-19 Public Health and Civil Liberties in Tension

JAMA

Authors
I. Glenn Cohen; Lawrence O. Gostin; Daniel J. Weitzner

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26/05/2020 Faqs
Industry Hotline: COVID-19 Diagnostic Tests and Shortages

US FOOD & DRUG

Authors
US FOOD & DRUG

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26/05/2020 Report
COVID-19 Guide for the Rehabilitation Clinician: A Review of Non-Pulmo...

COVID-19 Guide for the Rehabilitation Clinician: A Review of Non-Pulmonary Manifestations and Complications

American Journal of Physical Medicine & Rehabilitation

Authors
Lopez Marielisa, Bell Kathleen, Annaswamy Thiru, Juengst Shannon, Ifejika Nneka



ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – also known as COVID-19 – is primarily known for respiratory illness. While it is clear that patients with moderate to severe cases of COVID-19 will require pulmonary rehabilitation, physiatrists will need to consider effective management plans for COVID-19 survivors with extra-pulmonary involvement. This report will summarize key non-pulmonary considerations to guide rehabilitation clinicians who may be involved in the care of COVID-19 survivors with the best available early evidence.

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26/05/2020 Guidelines
Covid-19 and acute kidney injury in hospital: summary of NICE guidelin...

Covid-19 and acute kidney injury in hospital: summary of NICE guidelines

THE BMJ

Authors
Nicholas M Selby, Lui G Forni, Christopher M Laing, Kerry L Horne ,Rhys Evans, Bethany J Lucas, Richard J Fluck


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22/05/2020 Guidelines
Indicazioni per l’attuazione di misure contenitive del contagio da SAR...

Indicazioni per l’attuazione di misure contenitive del contagio da SARS-CoV-2 attraverso procedure di sanificazione di strutture non sanitarie (superfici, ambienti interni) e abbigliamento.

Ministero della Salute DIREZIONE GENERALE DELLA PREVENZIONE SANITARIA Ufficio 4

Authors
MINISTERO DELLA SALUTE

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22/05/2020 Viewpoint
Labor and Delivery Visitor Policies During the COVID-19 Pandemic Balan...

Labor and Delivery Visitor Policies During the COVID-19 Pandemic Balancing Risks and Benefits

JAMA

Authors
Kavita Shah Arora, Jaclyn T. Mauch, Kelly Smith Gibson

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21/05/2020 Guidelines
EASA-ECDC COVID-19 Operational guidelines for management of passengers...

EASA-ECDC COVID-19 Operational guidelines for management of passengers final

EASA (EUROPEAN UNION AVIATION SAFETY AGENCY)

Authors
EASA (EUROPEAN UNION AVIATION SAFETY AGENCY)

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18/05/2020 Viewpoint
Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV).....

Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV)...

JAMA

Authors
Francis S. Collins, Paul Stoffels

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15/05/2020 Scientific Brief
Multisystem inflammatory syndrome in children and adolescents temporal...

Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19

WORLD HEALTH ORGANIZATION

Authors
WORLD HEALTH ORGANIZATION

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13/05/2020 Research
Scope, quality, and inclusivity of clinical guidelines produced early ...

Scope, quality, and inclusivity of clinical guidelines produced early in the covid-19 pandemic: rapid review

The BMJ

Authors
Andrew Dagens, Louise Sigfrid, Erhui Cai, Sam Lipworth, Vincent Cheung,, Eli Harris, librarian, Peter Bannister,, Ishmeala Rigby, Peter Horby

ABSTRACT
Objective To appraise the availability, quality, and inclusivity of clinical guidelines produced in the early stage of the coronavirus disease 2019 (covid-19) pandemic.
Design Rapid review.
Data sources Ovid Medline, Ovid Embase, Ovid Global Health, Scopus, Web of Science Core Collection, and WHO Global Index Medicus, searched from inception to 14 Mar 2020. Search strategies applied the CADTH database guidelines search filter, with no limits applied to search results. Further studies were identified through searches of grey literature using the ISARIC network.
Inclusion criteria Clinical guidelines for the management of covid-19, Middle East respiratory syndrome (MERS), and severe acute respiratory syndrome (SARS) produced by international and national scientific organisations and government and non-governmental organisations relating to global health were included, with no exclusions for language. Regional/hospital guidelines were excluded. Only the earliest version of any guideline was included.
Quality assessment Quality was assessed using the Appraisal of Guidelines for Research and Evaluation (AGREE) II tool. The quality and contents of early covid-19 guidelines were also compared with recent clinical guidelines for MERS and SARS.
Results 2836 studies were identified, of which 2794 were excluded after screening. Forty two guidelines were considered eligible for inclusion, with 18 being specific to covid-19. Overall, the clinical guidelines lacked detail and covered a narrow range of topics. Recommendations varied in relation to, for example, the use of antiviral drugs. The overall quality was poor, particularly in the domains of stakeholder involvement, applicability, and editorial independence. Links between evidence and recommendations were limited. Minimal provision was made for vulnerable groups such as pregnant women, children, and older people.
Conclusions Guidelines available early in the covid-19 pandemic had methodological weaknesses and neglected vulnerable groups such as older people. A framework for development of clinical guidelines during public health emergencies is needed to ensure rigorous methods and the inclusion of vulnerable populations

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12/05/2020 Correspondence
Answering to the Call of Critically Ill Patients: Limiting Sonographer...

Answering to the Call of Critically Ill Patients: Limiting Sonographer Exposure to COVID-19 with Focused Protocols

ELSEVIER

Authors
Abigail Kaminski, Abby Payne, Sarah Roemer, Denise Ignatowski, Bijoy K.Khandheria



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09/05/2020 Scientifc Report
Criteria for releasing COVID-19 patients from isolation

WORLD HEALTH ORGANIZATION

Authors
WORLD HEALTH ORGANIZATION


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09/05/2020 Scientifc Report
Criteria for releasing COVID-19 patients from isolation

WORLD HEALTH ORGANIZATION

Authors
WORLD HEALTH ORGANIZATION


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08/05/2020 Open
Guidance for the management of adult patients with coronavirus disease...

Guidance for the management of adult patients with coronavirus disease 2019

Chinese Medical Journal

Authors
Jie-Ming Qu, Chen Wang, Bin Cao

ABSTRACT

In December 2019, a novel coronavirus was identified in Wuhan City, Hubei Province, China and later the disease was named coronavirus disease 2019 (COVID-19). On March 11, 2020, the World Health Organization (WHO) officially announced that COVID-19 had reached global pandemic status. This article summarized the understanding of the etiology, pathogenesis, epidemiology, clinical characteristics, diagnosis, treatment, rehabilitation, and prevention and control measures of COVID-19 based on the available data and anti-epidemic experience in China.

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08/05/2020 Articles
Quantifying SARS-CoV-2 transmission suggests epidemic control with dig...

Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing

Science

Authors
Luca Ferretti, Chris Wymant, Michelle Kendall, Lele Zhao, Anel Nurtay, Lucie Abeler-Dörner, Michael Parker, David Bonsall, Christophe Fraser

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06/05/2020 Articles
COVID-19: l’organizzazione del follow-up e la raccolta dati suglioutco...

COVID-19: l’organizzazione del follow-up e la raccolta dati suglioutcomes a medio e lungo termine.

SIMIT

Authors
SIMIT

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29/04/2020 Letter
The art of medicine Revisiting the 1957 and 1968 influenza pandemics

The Lancet

Authors
Mark Honigsbaum

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29/04/2020 Letter
Preliminary observations of anaesthesia ventilators use for prolonged ...

Preliminary observations of anaesthesia ventilators use for prolonged mechanical ventilation...

ELSEVIER

Authors
Aurélie Gouel-Cheron, CamilleCouffignale, Yoann Elmaleh, Elie Kantor, Philippe Montravers

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27/04/2020 Editorial
Global regulatory agility during covid-19 and other health emergencies

BMJ

Authors
Tippi K Mak, John CW Lim, Prapassorn Thanaphollert, Gugu N Mahlangu, Emer Cook, Murray M Lumpkin

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27/04/2020 Perspectives
Twentieth-Century Lessons for a Modern Coronavirus Pandemic

JAMA

Authors
Angel Desai

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24/04/2020 Overview
Availability of medicines during COVID-19 pandemic

EUROPEAN MEDICINE AGENCY

Authors
JAN JACOBS

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23/04/2020 Review
Recommendations for general surgery activities in a pandemic scenario ...

Recommendations for general surgery activities in a pandemic scenario (SARS-CoV-2)

BJS SOCIETY

Authors
F. Di Marzo, M. Sartelli, R. Cennamo, G. Toccafondi, F. Coccolini, G. La Torre, G. Tulli, M. Lombardi, M. Cardi

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22/04/2020 Articles
COVID-19 Rapid Diagnostic Tests: use in low resource settings

INSTITUTE OF TROPICAL MEDICINE ANTWERP

Authors
JAN JACOBS

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20/04/2020 Guidelines
Managing COVID-19 symptoms (including at the end of life) in the commu...

Managing COVID-19 symptoms (including at the end of life) in the community...

THE BMJ

Authors
National Institute for Health and Care Excellence (NICE) in collaboration with NHS England and NHS Improvement

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11/04/2020 Articles
Infectious Diseases Society of America Guidelines on the Treatment and...

Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19

ISDA

Authors
Adarsh Bhimraj, Rebecca L. Morgan, Amy Hirsch Shumaker, Valery Lavergne, Lindsey Baden, Vincent Chi-Chung Cheng, Kathryn M. Edwards, Rajesh Gandhi, Jason Gallagher, William J. Muller, John C. O’Horo, Shmuel Shoham, M. Hassan Murad, Reem A. Mustafa, Shahnaz Sultan, Yngve Falck-Ytter



ABSTRACT
Background: There are many pharmacologic therapies that are being used or considered for treatment of coronavirus disease 2019 (COVID-19). There is a need for frequently updated practice guidelines on their use, based on critical evaluation of rapidly emerging literature.
Objective: Develop evidence-based rapid guidelines intended to support patients, clinicians and other health-care professionals in their decisions about treatment and management of patients with COVID-19.
Methods: In March 2020, the Infectious Diseases Society of America (IDSA) formed a multidisciplinary guideline panel of infectious disease clinicians, pharmacists, and methodologists with varied areas of expertise. The process followed a rapid recommendation checklist. The panel prioritized questions and outcomes. Then a systematic review of the peer-reviewed and grey literature was conducted. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess the certainty of evidence and make recommendations.
Results: On April 11, 2020, IDSA released online initial treatment recommendations and narrative summaries of other treatments under evaluation. Since that time, the guideline panel and methodologists have continued to monitor the literature and issue updates and addendums to these guidelines in response to evolving research.
Conclusions: Since the inception of its work, the panel has expressed the overarching goal that patients be recruited into ongoing trials, which would provide much needed evidence on the efficacy and safety of various therapies for COVID-19, given that we could not make a determination whether the benefits outweigh harms for most treatments.

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09/04/2020 Editorial
Covid-19: should the public wear face masks?

THE BMJ

Authors
Babak Javid, Michael P Weekes, Nicholas J Matheson

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09/04/2020 Analysis
Face masks for the public during the covid-19 crisis

THE BMJ

Authors
Trisha Greenhalgh, Manuel B Schmid, Thomas Czypionka, Dirk Bassler, Laurence Gruer

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09/04/2020 Articles
Interim Guidance for Basic and Advanced Life Support in Adults, Childr...

Interim Guidance for Basic and Advanced Life Support in Adults, Children...

CIRCULATION

Authors
Dana P. Edelson, Comilla Sasson , Paul S. Chan, Dianne L. Atkins, Khalid Aziz, Lance B. Becker, Robert A. Berg, Steven M. Bradley, Steven C. Brooks, Adam Cheng, Marilyn Escobedo, Gustavo E. Flores, Saket Girotra, Antony Hsu, Beena D. Kamath-Rayne, Henry C. Lee, Rebecca E. Lehotzky, Mary E. Mancini, Raina M. Merchant, Vinay M. Nadkarni, Ashish R. Panchal, Mary Ann R. Peberdy, Tia T. Raymond, Brian Walsh, David S. Wang, Carolyn M. Zelop, Alexis Topjian

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07/04/2020 Research
High Contagiousness and Rapid Spread of Severe Acute Respiratory Syndr...

High Contagiousness and Rapid Spread of Severe Acute Respiratory Syndrome Coronavirus 2

CDC

Authors
Steven Sanche, Yen Ting Lin, Chonggang Xu, Ethan Romero-Severson, Nick Hengartner, Ruian Ke

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 is the causative agent of the 2019 novel coronavirus disease pandemic. Initial estimates of the early dynamics of the outbreak in Wuhan, China, suggested a doubling time of the number of infected persons of 6–7 days and a basic reproductive number (R0) of 2.2–2.7. We collected extensive individual case reports across China and estimated key epidemiologic parameters, including the incubation period. We then designed 2 mathematical modeling approaches to infer the outbreak dynamics in Wuhan by using high-resolution domestic travel and infection data. Results show that the doubling time early in the epidemic in Wuhan was 2.3–3.3 days. Assuming a serial interval of 6–9 days, we calculated a median R0 value of 5.7 (95% CI 3.8–8.9). We further show that active surveillance, contact tracing, quarantine, and early strong social distancing efforts are needed to stop transmission of the virus.

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07/04/2020 News
Covid-19: What is the evidence for cloth masks?

THE BMJ

Authors
Elisabeth Mahase

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06/04/2020 Circolare
Circolare sulle procedure semplificate per gli studi e gli usi compass...

Circolare sulle procedure semplificate per gli studi e gli usi compassionevoli...

AIFA

Authors
AIFA

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30/03/2020 Guidelines
Coping with stress during the 2019-nCoV outbreak

World Health Organization

World Health Organization

 

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27/03/2020 Guidelines
Consensus guidelines for managing the airway in patients with COVID-19

WILEY ONLINE LIBRARY

Authors
T. M. Cook K. El‐Boghdadly B. McGuire A. F. McNarry A. Patel A. Higgs

ABSTRACT

Severe acute respiratory syndrome-corona virus-2, which causes coronavirus disease 2019 (COVID-19), is highly contagious. Airway management of patients with COVID-19 is high risk to staff and patients. We aimed to develop principles for airway management of patients with COVID-19 to encourage safe, accurate and swift performance. This consensus statement has been brought together at short notice to advise on airway management for patients with COVID-19, drawing on published literature and immediately available information from clinicians and experts. Recommendations on the prevention of contamination of healthcare workers, the choice of staff involved in airway management, the training required and the selection of equipment are discussed. The fundamental principles of airway management in these settings are described for: emergency tracheal intubation; predicted or unexpected difficult tracheal intubation; cardiac arrest; anaesthetic care; and tracheal extubation. We provide figures to support clinicians in safe airway management of patients with COVID-19. The advice in this document is designed to be adapted in line with local workplace policies.

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25/03/2020 Report
COVID-19: An executive report

ACCADEMIA DEI LINCEI

Authors
Maurizio Cecconi, Guido Forni, Alberto Mantovani

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23/03/2020 Link
Coronavirus COVID-19 (SARS-CoV-2)

Johns Hopkins Medicine

Authors
Paul G. Auwaerter

Read More »

19/03/2020 Press Release
Call to pool research resources into large multi-centre, multi-arm cli...

Call to pool research resources into large multi-centre, multi-arm clinical trials to generate sound evidence on COVID-19 treatments

European Medicines Agency Science Medicine Health

European Medicines Agency Science Medicine Health

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12/03/2020 Articles
Managing the Respiratory care of patients with COVID-19

ITS (ITALIAN THORACIC SOCIETY)

Authors
Harari Sergio Alfonso, Vitacca Michele, Blasi Francesco, Centanni Stefano, Santus Pier Achille, Tarsia Paolo

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10/03/2020 Technical Report
Novel coronavirus (SARS-CoV-2) Discharge criteria for confirmed COVID-...

Novel coronavirus (SARS-CoV-2) Discharge criteria for confirmed COVID-19 cases...

ECDC

Authors
ECDC

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02/03/2020 Interim guidance
Laboratory testing for coronavirus disease 2019 (COVID-19) in suspecte...

Laboratory testing for coronavirus disease 2019 (COVID-19) in suspected human cases

WORLD HEALTH ORGANIZATION

Authors
WORLD HEALTH ORGANIZATION

Read More »

18/02/2020 Guidelines
Surface sampling of coronavirus disease (COVID-19): A practical “how t...

Surface sampling of coronavirus disease (COVID-19): A practical “how to” protocol for health care and public health professionals

World Health Organization

World Health Organization

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10/02/2020 Guidelines
Guidelines for the use of non-pharmaceutical measures to delay and mit...

Guidelines for the use of non-pharmaceutical measures to delay and mitigate the impact of 2019-nCoV

ECDC TECHNICAL REPORT

Authors
ECDC TECHNICAL REPORT

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05/02/2020 Guidelines
Risk Assessment of Novel Coronavirus COVID-19 Outbreaks Outside China

MDPI - Journal of Clinical Medicine

Authors
Péter Boldog, Tamás Tekeli, Zsolt Vizi, Attila Dénes, Ferenc A. Bartha and Gergely Röst

Abstract:

We developed a computational tool to assess the risks of novel coronavirus outbreaks outside of China. We estimate the dependence of the risk of a major outbreak in a country from imported cases on key parameters such as: (i) the evolution of the cumulative number of cases in mainland China outside the closed areas; (ii) the connectivity of the destination country with China, including baseline travel frequencies, the effect of travel restrictions, and the efficacy of entry screening at destination; and (iii) the efficacy of control measures in the destination country (expressed by the local reproduction number Rloc). We found that in countries with low connectivity to China but with relatively high Rloc, the most beneficial control measure to reduce the risk of outbreaks is a further reduction in their importation number either by entry screening or travel restrictions. Countries with high connectivity but low Rloc benefit the most from policies that further reduce Rloc. Countries in the middle should consider a combination of such policies. Risk assessments were illustrated for selected groups of countries from America, Asia, and Europe. We investigated how their risks depend on those parameters, and how the risk is increasing in time as the number of cases in China is growing.

Keywords:
novel coronavirus; transmission; risk assessment; interventions; travel; outbreak; COVID-19; compartmental model; branching process

Target audience
Public health authorities in the EU/EEA Member States (MS) and the UK.

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03/02/2020 Guidelines
COVID-19 rapid guideline: managing symptoms (including at the end of l...

COVID-19 rapid guideline: managing symptoms (including at the end of life) in the community

NICE guideline

Authors
Péter Boldog, Tamás Tekeli, Zsolt Vizi, Attila Dénes, Ferenc A. Bartha and Gergely Röst

Abstract:
The purpose of this guideline is to provide recommendations for managing COVID‑19 symptoms for patients in the community, including at the end of life. It also includes recommendations about managing medicines for these patients, and protecting staff from infection. This guideline is for: health and care practitioners health and care staff involved in planning and delivering services commissioners The recommendations bring together existing national and international guidance and policies advice from specialists working in the NHS from across the UK. These include people with expertise and experience of treating patients for the specific health conditions covered by the guidance during the current COVID-19 pandemic.

Keywords:
novel coronavirus; transmission; risk assessment; interventions; travel; outbreak; COVID-19; compartmental model; branching process

Target audience
Public health authorities in the EU/EEA Member States (MS) and the UK.

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15/03/2016 Articles
Impact analysis studies of clinical prediction rules relevant to prima...

Impact analysis studies of clinical prediction rules relevant to primarycare...

BMJ

Authors
Emma Wallace, Maike J M Uijen, Barbara Clyne, Atieh Zarabzadeh, Claire Keogh

ABSTRACT
Objectives Following appropriate validation, clinical prediction rules (CPRs) should undergo impact analysis to evaluate their effect on patient care. The aim of this systematic review is to narratively review and critically appraise CPR impact analysis studies relevant to primary care. Setting Primary care. Participants Adults and children. Intervention Studies that implemented the CPR compared to usual care were included. Study design Randomised controlled trial (RCT), controlled before–after, and interrupted time series. Primary outcome Physician behaviour and/or patient outcomes. Results A total of 18 studies, incorporating 14 unique CPRs, were included. The main study design was RCT (n=13). Overall, 10 studies reported an improvement in primary outcome with CPR implementation. Of 6 musculoskeletal studies, 5 were effective in altering targeted physician behaviour in ordering imaging for patients presenting with ankle, knee and neck musculoskeletal injuries. Of 6 cardiovascular studies, 4 implemented cardiovascular risk scores, and 3 reported no impact on physician behaviour outcomes, such as prescribing and referral, or patient outcomes, such as reduction in serum lipid levels. 2 studies examined CPRs in decision-making for patients presenting with chest pain and reduced inappropriate admissions. Of 5 respiratory studies, 2 were effective in reducing antibiotic prescribing for sore throat following CPR implementation. Overall, study methodological quality was often unclear due to incomplete reporting. Conclusions Despite increasing interest in developing and validating CPRs relevant to primary care, relatively few have gone through impact analysis. To date, research has focused on a small number of CPRs across few clinical domains only

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