The anthracyclines enjoy a longer than 40 years record of longevity and still play an undisputed key role in the treatment of breast cancer and many other tumors. Unfortunately however, anthracyclines will also induce cardiomyopathy and congestive heart failure often refractory to common medications, and combining anthracyclines with new generation chemotherapeutics or targeted therapies may further aggravate cardiotoxicity. The molecular and clinical aspects of anthracycline cardiotoxicity therefore pose a number of questions that only in part have been answered: why is the heart so vulnerable and what can be done to protect it while leaving the tumors exposed to anthracyclines? What can be done to identify patients carrying an increased risk to develop cardiotoxicity? What kind of synergism links the old anthracyclines to the new anticancer agents? And finally, do we have a better anthracycline? The Menarini Foundation wishes to contribute to this debate by hosting an "International Workshop on Anthracycline Cardiotoxicity: Molecular Mechanisms and Clinical Correlates", organized by Prof. Giorgio Minotti (University of Chieti, Italy) and co-chaired by Dr. Narine Sarvazyan (The George Washington University, Washington DC). This Workshop is aimed at fostering interactions between preclinical and clinical investigators with interest in the molecular mechanisms, pathophysiology and clinical readouts of cardiotoxicity induced by anthracyclines, whether administered as single agents or in combination with other chemotherapeutics. The Scientific Program is structured as a full circle from Clinical Aspects (session I) to Molecular Mechanisms (session II) and Cardioprotection (session III). Each session will be followed by a plenary Forum that will serve an opportunity to exchange ideas and challenge concepts and research directions. Hopefully, this approach will form the basis to incorporate the viewpoints of clinicians and preclinical investigators in a comprehensive and productive framework. The Workshop will take place October 20th - 21st, 2006, at Villa Olmo, a beautiful neoclassic venue on the Lake of Como. Villa Olmo is home of a scientific center dedicated to Alessandro Volta (1745-1827), a pioneer in the field of electricity and inventor of the battery. We trust that the spiritual patronage of Alessandro Volta will "electrify" all attendees and will offer resuscitating "voltages" to improve the molecular understanding and clinical handling of anthracycline Anthracycline Cardiotoxicity: Molecular Mechanisms and Clinical Correlates cardiotoxicity. We have the pleasure to announce the organization of this Workshop and warmly invite you to attend it in a scenical and historical environment.
Giorgio Minotti and Narine Sarvazyan Co-Chairs